NEUTROPHIL ELASTASE IN TRACHEAL ASPIRATES OF INFANTS WITH RESPIRATORY DISTRESS SYNDROME (RDS)
نویسندگان
چکیده
منابع مشابه
Could mean platelet volume predict developing of bronchopulmonary dysplasia in preterm infants with respiratory distress syndrome?
Introduction: some studies have suggested correlation between MPV index and inflammatory diseases such as rheumatoid arthritis in adults. Though bronchopulmonary dysplasia is also an inflammatory disease which develops in preterm neonates with Respiratory distress syndrome, we decided to study the possible correlation between the mean platelet volume (MPV) and the occurrence of bronchopulmonary...
متن کاملPlasma Neutrophil Elastase and Elafin Imbalance Is Associated with Acute Respiratory Distress Syndrome (ARDS) Development
BACKGROUND We conducted an exploratory study of genome-wide gene expression in whole blood and found that the expression of neutrophil elastase inhibitor (PI3, elafin) was down-regulated during the early phase of ARDS. Further analyses of plasma PI3 levels revealed a rapid decrease during early ARDS development. PI3 and secretory leukocyte proteinase inhibitor (SLPI) are important low-molecular...
متن کاملHuman neutrophil elastase and lung surfactant in acute respiratory distress syndrome
Human Neutrophil Elastase (HNE) is one of the main proteases secreted into the alveolar space by infiltrated neutrophils during several inflammatory lung diseases such as cystic fibrosis, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Consequently, a number of therapeutic approaches based on the specific inhibition of HNE are currently under investigation. The present w...
متن کاملEffective Factors of INSURE Method Failure in Treatment of Respiratory Distress Syndrome in Preterm Infants
Background INtubate-SURfactant-Extubate (INSURE) method is one of the effective methods in treatment of infants with respiratory distress syndrome (RDS). This study was performed to predict risk factors for the failure of INSURE method in treatment of RDS in preterm infants. Materials and Methods: In this cross-sectional study, 192 infants who born between July 2011 and April 2016 at women and...
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Acute respiratory distress syndrome is a serious condition that can arise following direct or indirect lung injury. It is heterogeneous and has a high mortality rate. Supportive care is the mainstay of treatment and there is no definitive pharmacological treatment as yet. Sivelestat is a neutrophil elastase inhibitor approved in Japan and the Republic of Korea for acute lung injury, including a...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1992
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199211000-00111